Methods for assessing and treating leukemia

Details Methods for assessing and treating leukemia Methods for assessing and treating leukemia

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/47 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2472846

Methods for treating cancer, and preferably hematological malignancy, patients include analyzing gene expression profiles and/or molecular markers of a patient to determine whether the patient is likely to respond to treatment with farnesyl transferase inhibitor (FTI) and, optionally, other therapeutics. The methods are also useful for monitoring patient therapy and for selecting a course of therapy. Genes modulated in response to FTI treatment are provided and are used in formulating the profiles.

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