Methods for assessing cardiovascular status and compositions...

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01) C07K 14/575 (2006.01) C07K 14/72 (2006.01) C12N 9/48 (2006.01)

Patent

CA 2285671

The present invention provides methods for assessing cardiovascular status in an individual, which comprise determining the sequence at one or more polymorphic positions within the human genes encoding angiotensin converting enzyme (ACE), angiotensinogen (AGT), and/or type 1 angiotensin II receptor (AT~). The invention also provides isolated nucleic acids endoding ACE, AGT, and AT~ polymorphisms, nucleic acid probes that hybridize to polymorphic positions, kits for the prediction of cardiovascular status, and nucleic acid and peptide targets for use in identifying candidate cardiovascular drugs.

La présente invention a trait à des procédés permettant d'évaluer l'état cardiovasculaire d'un individu, qui comportent les étapes consistant à déterminer la séquence, située à une ou plusieurs positions polymorphes dans des gènes humains, codant pour l'enzyme de conversion d'angiotensine (ACE), pour l'angiotensinogène (AGT), et/ou pour le récepteur d'angiotensine II de type 1 (AT1). L'invention a également trait à des acides nucléiques isolés codant pour des polymorphismes d'ACE, d'AGT et d'AT1, à des sondes d'acides nucléiques s'hybridant à des positions polymorphes, à des trousses de prédiction d'état cardiovasculaire, et à des cibles peptidiques et d'acides nucléiques utiles pour l'identification de médicaments cardiovasculaires candidats.

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