Methods for cancer prognosis

Details Methods for cancer prognosis Methods for cancer prognosis

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61P 35/00 (2006.01) C12Q 1/00 (2006.01)

Patent

CA 2600908

A method for assessing prognosis in a subject having a breast tumor comprises determining the level of expression of at least one Notch receptor gene, Notch ligand gene or Notch signaling target gene. A method of treating a subject suffering from a breast tumor associated with increased Notch signaling comprises administering to the subject an effective amount of an inhibitor of Notch signaling.

L'invention concerne une méthode permettant d'établir un pronostic pour un sujet présentant une tumeur du sein, consistant à déterminer le niveau d'expression d'au moins un gène de récepteur Notch, un gène d'un ligand, ou un gène cible de la signalisation Notch. L'invention concerne en outre une méthode permettant de traiter un sujet souffrant d'une tumeur du sein associé à une augmentation de la signalisation Notch, consistant à administrer à ce sujet une dose efficace d'un inhibiteur de la signalisation Notch.

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