Methods for cloning mammals using remodeling factors

Details Methods for cloning mammals using remodeling factors Methods for cloning mammals using remodeling factors

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A01K 67/00 (2006.01) A01K 67/027 (2006.01) C12N 5/00 (2006.01) C12N 5/02 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2450652

Methods and compositions are provided for remodeling nuclear donor material used in nuclear transfer procedures. By exposing donor chromatin to one or more exogenous remodeling factors, the limited ability of mammalian oocytes to remodel the chromatin of differentiated cells, including fetal and live-born somatic cells, can be increased, resulting in dramatically improved cloning efficiencies.

L'invention concerne des procédés et des compositions destinés à remodeler une matière nucléaire donneuse utilisée dans des procédures de transfert nucléaire. Par exposition de la chromatine donneuse à un ou plusieurs facteurs de remodelage exogènes, la capacité limitée des ovocytes mammaliens à remodeler la chromatine de cellules différenciées, notamment les cellules foetales et somatiques nées vivantes, peut être augmentée, ce qui entraîne des rendements de clonage considérablement améliorés.

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