A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/19 (2006.01) A61K 38/04 (2006.01) A61P 31/18 (2006.01) C07K 14/47 (2006.01) C07K 14/52 (2006.01) C12N 15/10 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2459367
The present invention provides a method for the design and/or the selection of agonist or antagonist chemokine variants combining a phage display technology and a screening on living cells expressing the receptor of the corresponding native chemokine. It also provides RANTES variants having agonist properties towards said receptor, and methods for preventing and/or curing viral diseases, as well as clues for preventing and/or curing inflammatory or malignant diseases.
La présente invention porte sur un procédé de conception et/ou de sélection de variants de chimiokines d'agonistes ou antagonistes combinant une méthode d'expression à la surface des phages et de criblage sur des cellules vivantes exprimant le récepteur de la chimiokine native correspondante. L'invention porte également sur des variants de RANTES possédant des propriétés agonistes envers ce récepteur, et sur des procédés pour prévenir et/ou guérir les maladies virales, ainsi que les maladies inflammatoires ou affections malignes.
Debre Patrice
Dorgham Karim
Gorochov Guy
Hartley Oliver
Offord Robin
Goudreau Gage Dubuc
Universite de Geneve
Universite Pierre Et Marie Curie (paris Vi)
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