A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 33/16 (2006.01) A61K 31/425 (2006.01) A61K 31/429 (2006.01) A61K 31/513 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2430489
The invention provides an improved method for potentiating the antineoplastic activity of 5-fluorouracil with levamisole, or with an analogue thereof. Specifically, the invention provides regimens wherein levamisole is administered contemporaneously with the administration of 5-fluorouracil, thereby increasing the exposure of tumor tissue to the simultaneous presence of the two drugs. The invention further provides methods for the parenteral administration of levamisole, thereby overcoming the disadvantages associated with inter-patient variability in the bioavailability of oral.
L'invention concerne un procédé amélioré de potentialisation de l'activité antinéoplastique du 5-fluorouracile avec du lévamisole, ou avec un analogue de ce composé. Elle concerne spécifiquement des régimes dans lesquels du lévamisole est administré de façon conjuguée à l'administration de 5-fluorouracile, ce qui permet d'augmenter l'exposition d'un tissu tumoral à la présence simultanée des deux médicaments. Elle concerne aussi des procédés d'administration parentérale de lévamisole permettant d'éviter les désavantages associés aux variabilités entre patients de la biodisponibilité par voie orale.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Targent Inc.
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