A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 38/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2562756
The present invention relates generally to methods of inhibiting angiogenesis in a patient by administering an effective angiogenesis-inhibiting amount of a thrombin inhibitor, and to the treatment of disease states that result from uncontrolled cell proliferation by administering a thrombin inhibitor alone or co-administering a thrombin inhibitor with an anticancer or cytotoxic agent. Specifically, the thrombin inhibitors used in the methods of the present invention are hirudins.
L'invention concerne généralement des méthodes d'inhibition d'angiogenèse chez un patient. Ces méthodes consistent à administrer une quantité d'inhibition d'angiogenèse efficace d'un inhibiteur de trombine. L'invention concerne également le traitement d'états pathologiques résultant d'une prolifération cellulaire non contrôlée, par l'administration d'un inhibiteur de trombine seule ou par la co-administration d'un inhibiteur de trombine présentant un agent anticancéreux ou cytotoxique. En particulier, les inhibiteurs de trombine utilisés dans les méthodes de l'invention sont des hirudines.
Canyon Pharmaceuticals Inc.
Canyon Pharmaceuticals Group Ag
Gowling Lafleur Henderson Llp
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