Methods for controlling human endothelial cell proliferation...

Details Methods for controlling human endothelial cell proliferation... Methods for controlling human endothelial cell proliferation...

A - Human Necessities

61

K

167/103

A61K 38/19 (2006.01) A61K 38/22 (2006.01) A61K 38/49 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2028825

2028825 9012585 PCTABS00002 The present invention is directed to the use of a recently discovered cytokine, Oncostatin M, to control endothelial cell immunogenicity, fibrinolytic activity, proliferation and cytokine synthesis, and to its use in the treatment of a variety of human vascular and immune system disorders involving the vascular endothelium, as well as its use in the treatment of neoplastic disease. The method of the invention includes the use of mature, hybrid, modified or truncated forms of Oncostatin M as well as Oncostatin M analogs. The invention is described by way of examples in which the efficacy of such compounds is evaluated using various in vitro assay systems.

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