A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2643790
The present invention relates to the use of cytoxicity based on the effector function of anti-EphA4 antibodies. Specifically, the present invention provides methods and pharmaceutical compositions that comprise an anti-EphA4 antibody as an active ingredient for damaging EphA4-expressing cells using antibody effector function. Since EphA4 is strongly expressed in pancreatic cancer cells, the present invention is particularly useful in pancreatic cancer therapies.
La présente invention concerne l'utilisation de la cytotoxicité basée sur la fonction effectrice des anticorps anti-EphA4. Spécifiquement, la présente invention concerne des procédés et des compositions pharmaceutiques qui comprennent un anticorps anti-EphA4 en tant que principe actif pour dégrader des cellules qui expriment l'EphA4 en utilisant la fonction effectrice de l'anticorps. Étant donné que l'EphA4 est fortement exprimé dans les cellules de cancer du pancréas, la présente invention est particulièrement utile dans les traitements du cancer du pancréas.
Hiroshima Shinichi
Kishi Yoshiro
Kuhara Motoki
Nakatsuru Shuichi
Nishida Shiyo
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Oncotherapy Science Inc.
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