A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4174 (2006.01) A61K 31/136 (2006.01) A61K 31/216 (2006.01) A61K 31/35 (2006.01)
Patent
CA 2530763
Disclosed herein are novel methods for preventing or delaying preterm uterine contractions in a pregnant mammal. Also disclosed are novel methods for inducing uterine contractions in a pregnant mammal. In each case, control of uterine smooth muscle contractility is achieved by specifically targeting the MAPK ERK signal transduction cascade. Inactivation of the cascade is disclosed as a novel method for delaying labor. Activation of the MAPK ERK pathway is disclosed as a novel method for inducing labor.
L'invention concerne des méthodes nouvelles de prévention ou de retardement des contractions utérines prématurées chez un mammifère en état de grossesse. L'invention porte également sur des nouvelles méthodes d'induction de contractions utérines chez un mammifère en état de grossesse. Dans chaque cas, la commande de la contractilité du muscle lisse de la paroi utérine est obtenue par le ciblage spécifique de la cascade de transduction de signal MAPK ERK. L'inactivation de la cascade est présentée comme une nouvelle méthode de retardement du travail. L'activation de la voie MAPK ERK est décrite comme une nouvelle méthode d'induction du travail.
Li Yunping
Morgan Kathleen
Boston Biomedical Research Institute
Goudreau Gage Dubuc
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