A - Human Necessities – 61 – N
Patent
A - Human Necessities
61
N
A61N 1/32 (2006.01)
Patent
CA 2400325
A variety of methods for transporting different agents such as pharmaceutical agents, nutrients and genetic materials across a tissue are provided. The methods utilize an AC signal to maintain a substantially constant electrical state in a region of the tissue through which transport occurs, thereby allowing agent to be transported across the tissue in a controlled and predictable manner. Certain methods include an optional AC or DC prepulse signal to initially achieve the target electrical state. An optional DC offset signal can also be included to assist in promoting transfer of the agent. The methods have utility in a variety of different clinical settings and applications.
L'invention concerne divers procédés visant à transporter différents agents tels que des agents pharmaceutiques, des nutriments et des matières génétiques à travers un tissu. Les procédés utilisent un signal de courant alternatif pour maintenir un état électrique sensiblement constant dans une zone du tissu à travers laquelle le transport se produit, pour permettre un transport de l'agent à travers le tissu de manière contrôlée et prévisible. Certains procédés comprennent un signal de préimpulsion facultatif de courant alternatif ou de courant continu pour atteindre initialement l'état électrique voulu. Un signal de décalage facultatif en courant continu peut aussi être inclus pour contribuer à activer le transfert de l'agent. Les procédés sont utiles dans diverses situations et applications cliniques différentes.
Higuchi William I.
Li S. Kevin
Song Yang
Zhu Honggang
Ridout & Maybee Llp
University Of Utah Research Foundation
LandOfFree
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