Methods for delivering volatile anesthetics for regional...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/02 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 31/07 (2006.01) A61P 23/00 (2006.01)

Patent

CA 2663857

The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic such as a halogenated ether compound in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered to the subject to anesthetize the subject prior to a surgery. In certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, xenon, and mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.

La présente invention concerne des procédés destinés à réduire la douleur chez un sujet en ayant besoin par la libération, par exemple, par voie intrathécale ou épidurale, d'un anesthésiant volatil tel qu'un composé à base d'éther halogéné en une quantité efficace pour réduire la douleur. La douleur chronique ou aiguë peut être traitée, ou bien l'anesthésiant peut être administré au sujet afin de l'anesthésier avant une chirurgie. Dans certains modes de réalisation, on peut utiliser de l'isoflurane, de l'halothane, de l'enflurane, du sévoflurane, du desflurane, du méthoxyflurane, du xénon et des mélanges de ceux-ci. Des régimes de dosage comprenant une administration unique, continue et/ou périodique sont envisagés.

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