Methods for detecting a mycobacterium tuberculosis infection

Details Methods for detecting a mycobacterium tuberculosis infection Methods for detecting a mycobacterium tuberculosis infection

G - Physics

01

N

G01N 33/569 (2006.01)

Patent

CA 2732750

Methods for detecting an infection with Mycobacterium tuberculosis (Mtb) in a subject are disclosed, wherein the subject is a child, a subject with a latent Mycobacterium tuberculosis infection. Method are also disclose for detecting an extra-pulmonary Mycobacterium tuberculosis infection in a subject. The methods include detecting the presence of CD8+T cells that specifically recognize an Mtb polypeptide. The methods include in vitro assays for detecting the presence of CD8+T cells in a biological sample.

Linvention concerne des méthodes permettant de détecter une infection par le bacille de Koch (Mtb) chez un sujet, le sujet étant un enfant présentant une infection latente par le bacille de Koch. Des méthodes permettant de détecter une infection extra-pulmonaire par le bacille de Koch chez un sujet sont également décrites. Les méthodes comprennent la détection de la présence de lymphocytes T CD8+ qui reconnaissent spécifiquement un polypeptide Mtb. Les méthodes comprennent des essais in vitro permettant de détecter la présence de lymphocytes T CD8+ dans un échantillon biologique.

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