Methods for detecting and imaging a temperature of an object...

G - Physics – 01 – K

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G01K 7/36 (2006.01) A61K 49/06 (2006.01) G01K 11/00 (2006.01) G01R 33/28 (2006.01) G01R 33/48 (2006.01)

Patent

CA 1211791

METHODS FOR DETECTING AND IMAGING A, TEMPERATURE OF AN OBJECT BY NUCLEAR MAGNETIC RESONANCE ABSTRACT OF THE DISCLOSURE A novel and improved method to detect indirectly a temperature of an object employing nuclear magnetic resonance techniques (NMR). The method involves obtaining an NMR spectrum to determine chemical shift, relaxation times, spin-spin coup- lings or quadrupole couplings for an element of a compound having at least one conformational isomer wherein the compound is influenced by a temperature of the object. Uniquely, the present invention may detect temperature in the body of an animal. Further, the present invention discloses a novel method to determine and monitor thermal physiological states in an animal as well as determine and monitor thermal states in an object. Because of the unique and advantageous non-invasive, non-destructive and non-ionizing properties, the present inven- tion may be employed in an object or animal continuously. The preset invention also provides for the thermal imaging, or NMR thermography, by one-, two-, or three-dimensional reconstruction techniques from chemical shift, relaxation times, (e.g., T1 or T2,) spin-spin couplings and quadrupole couplings for an element of a compound having at least one conformational isomer in an object or animal influenced by a temperature in the object or animal. The methods disclosed are applicable to inanimate and animate solids.

447536

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