C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 45/00 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2451483
This invention provides methods for detecting or inferring the presence of malignant or premalignant cells in a human wherein the malignant or premalignant cells express COX-2. The methods of the invention detect extracellular COX-2 RNA in blood, plasma, serum, and other bodily fluids. The inventive methods are useful for aiding detection, diagnosis, monitoring, treatment, or evaluation of neoplastic disease, and for identifying individuals for whom COX-2 directed therapies would be beneficial.
L'invention concerne des méthodes de détection ou d'induction de la présence de cellules malignes ou précancéreuses chez un humain, cellules malignes ou précancéreuses exprimant COX-2. Les méthodes de l'invention permettent la détection de l'ARN de COX-2 extra-cellulaire dans le sang, le plasma, le sérum et d'autres liquides organiques. Les méthodes de l'invention sont utiles pour aider à la détection, au diagnostic, à la surveillance, au traitement ou à l'évaluation d'affection néoplasique, et pour identifier des sujets pour lesquels des thérapies dirigées contre le COX-2 seraient bénéfiques.
Mbm Intellectual Property Law Llp
Oncomedx Inc.
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