Methods for detecting and treating the early onset of...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C12N 5/071 (2010.01) A61K 45/00 (2006.01) C12Q 1/02 (2006.01) C40B 30/04 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2450809

Certain aspects of the invention relate to methods for determining a subject's susceptibility to the early onset or progression of aging-related conditions. In certain aspects the invention relates to accessing the genotype of a subject with respect to an allele of IL-1 pattern 1, pattern 2 and/or pattern 3. In other aspect, the invention relates to methods for selecting a therapeutic regimen, identifying age-related biomarkers, monitoring the progress of age-related conditions and identifying therapeutics for delaying or diminishing the onset of aging-related conditions.

Certains modes de réalisation de l'invention concernent des méthodes de détermination de la réceptivité d'un sujet à l'apparition précoce ou à la progression d'états liés au vieillissement. Certains modes de réalisation de l'invention concernent l'accès au génotype d'un sujet par rapport à un allèle de l'interleukine-1 (IL-1) modèle 1, modèle 2 et/ou modèle 3. Dans un autre mode de réalisation, l'invention concerne des méthodes de sélection d'un régime thérapeutique, d'identification de marqueurs biologiques liés au vieillissement, de surveillance de la progression d'états liés au vieillissement et d'identification de thérapies permettant de retarder ou de diminuer l'apparition d'états liés au vieillissement.

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