Methods for detecting breast and ovarian cancer

Details Methods for detecting breast and ovarian cancer Methods for detecting breast and ovarian cancer

G - Physics

01

N

G01N 33/574 (2006.01)

Patent

CA 2497058

Kallikrein 5 constitutes a novel biomarker for diagnosis, treatment and monitoring of breast and ovarian cancer. A method is provided for diagnosing and monitoring breast or ovarian cancer or a predisposition to breast or ovarian cancer, in a subject comprising detecting kallikrein 5 in a sample from the subject. Imaging methods, screening methods for test agents for inhibiting breast or ovarian cancer, and therapeutic applications based on kallikrein 5 are also described.

Selon cette invention, la kallicréine 5 constitue un nouveau biomarqueur destiné au diagnostic, au traitement et à la surveillance du cancer du sein et des ovaires. Ladite invention concerne une méthode destinée à diagnostiquer et surveiller un cancer du sein ou des ovaires ou une prédisposition au cancer du sein ou des ovaires chez un sujet, cette méthode consistant à détecter la kallicréine 5 dans un échantillon provenant du sujet. L'invention a aussi pour objet des méthodes d'imagerie, des méthodes de criblage d'agents d'essai élaborées pour inhiber le cancer du sein ou des ovaires, et des applications thérapeutiques reposant sur la kallicréine 5.

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