Methods for detecting calpain activation and indentifying...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 239/54 (2006.01) C08F 12/26 (2006.01) G03F 7/027 (2006.01) G03F 7/038 (2006.01)

Patent

CA 2185144

Multifunctional vinylbenzyl and vinylphenyl pendant thymine (and uracil) groups are disclosed. The monomers can be used for the production of polymers useful in photoresist and other compositions as a function of the cross-linking reactivity of the pendant groups. Images in polymer are provided by exposure to actinic radiation (e.g., UV), containing such polymer and by solvent removal of non-exposed regions.

L'invention concerne des méthodes pour détecter l'activation de la calpaïne, consistant à mesurer les niveaux des produits de dégradation de la spectrine produits par la calpaïne, en utilisant des anticorps qui se fixent spécifiquement à ces produits de dégradation de la spectrine, mais pas à la spectrine intacte, ni aux produits de dégradation de la spectrine produits par d'autres protéases. L'invention concerne également des coffrets pour diagnostiquer des maladies associées à une activation trop élevée de la calpaïne, ainsi que des méthodes pour effectuer une évaluation préliminaire des médicaments qui pourraient être utiles pour le traitement de ces maladies.

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