Methods for detecting cell apoptosis

Details Methods for detecting cell apoptosis Methods for detecting cell apoptosis

C - Chemistry, Metallurgy

12

N

C12N 9/10 (2006.01) C07K 7/06 (2006.01) C07K 16/40 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/04 (2006.01) C12Q 1/06 (2006.01) G01N 33/53 (2006.01) G01N 33/554 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2270866

Methods for the biochemical and immunohistochemical detection of cell apoptosis are described. The methods utilize the detection and measurement of polypeptide fragments generated during apoptosis. Conditions associated with apoptosis may be detected by the methods of this invention. Methods are also presented for the screening of potential therapeutic compounds which inhibit or stimulate apoptosis. Kits for detection of apoptosis and diagnosis of diseases are also provided.

La présente invention concerne des procédés biochimiques et immunohistochimiques de détection de l'apoptose cellulaire. Ces procédés ont recours à la détection et à l'évaluation de fragments polypeptides générés pendant l'apoptose. Les procédés de l'invention permettent de détecter les conditions correspondant à l'apoptose. L'invention concerne également des procédés permettant de recherches des agents thérapeutiques potentiels inhibant ou stimulant l'apoptose. L'invention concerne enfin des nécessaires de détection d'apoptose et de diagnostic de maladies.

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