A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/24 (2006.01) A61K 49/00 (2006.01) A61K 51/00 (2006.01) A61M 36/14 (2006.01)
Patent
CA 2329352
Improved methods for detecting lesions in dense breast tissue are disclosed. The methods of the invention generally feature administration to a subject of an LHRH antagonist in an amount and for a period of time sufficient to reduce the density of breast tissue prior to generating an image of the breast tissue, for example by mammography, to detect a lesion in the breast tissue. Packaged formulations for reducing breast density in a subject prior to generating an image of the subject's breast tissue, comprising an LHRH antagonist packaged with instructions for using the LHRH antagonist to reduce breast density in a subject prior to imaging the breast tissue, are also disclosed.
La présente invention concerne des méthodes améliorées de détection de lésions dans le tissu mammaire dense. De façon générale, ces méthodes consistent à administrer à un sujet une dose suffisante, pendant un laps de temps suffisant, d'un antagoniste de la lulibérine de manière à réduire la densité du tissu mammaire avant de mise en oeuvre d'une technique d'inmagerie, telle qu'une mamographie, en vue de la détection d'une lésion. L'invention concerne également des formulations conditionnées qui sont destinées à réduire la densité du tissu mamaire chez le sujet avant visualisation et qui comprennent un antagonsite de la lulibérine fourni avec des instructions d'utilisation pour administration dudit antagonistes dans les conditions susmentionnées.
Gowling Lafleur Henderson Llp
Praecis Pharmaceuticals Incorporated
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