Methods for detecting mitochondrial mutations diagnostic for...

Details Methods for detecting mitochondrial mutations diagnostic for... Methods for detecting mitochondrial mutations diagnostic for...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C07H 21/04 (2006.01)

Patent

CA 2281859

The present invention relates to methods of detecting genetic mutations in mitochondrial cytochrome oxidase c genes that segregate with Alzheimer's Disease and methods for determining the amount of heteroplasmy of mitochondrial nucleic acid. The invention provides methods for detecting such mutations, as a diagnostic for Alzheimer's Disease, either before or after the onset of clinical symptoms.

L'invention concerne des méthodes de détection de mutations génétiques dans les gènes de la cytochrome oxydase c, qui se séparent avec la maladie d'Alzheimer et des méthodes pour déterminer l'ampleur de l'hétéroplasmie de l'acide nucléique mitochondrial. L'invention porte aussi sur des méthodes de détection desdites mutations, comme diagnostic de la maladie d'Alzheimer, avant ou après l'apparition des symptômes cliniques.

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