A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/28 (2006.01) C07K 16/22 (2006.01) C12N 15/11 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2342280
The present invention relates to methods for detecting, preventing, and treating the progression of pathologies characterized by an accumulation of the extracellular matrix components by providing an agent to regulate, inhibit, or modulate the activity of Connective Tissue Growth Factor (CTGF). The method of the present invention is directed to treating kidney fibrosis and associated renal disorders, in particular, complications associated with diabetes and hypertension.
La présente invention concerne des méthodes de détection, de prévention et de traitement de la progression de maladies se caractérisant par une accumulation de composants de la matrice extracellulaire, la méthode consistant à administrer un agent pour réguler, inhiber ou moduler l'activité du facteur de croissance du tissu conjonctif (CTGF). La méthode selon la présente invention est destinée au traitement de la fibrose des reins et de troubles rénaux associés, notamment de complications associées au diabète et à l'hypertension.
Denichilo Mark
Riser Bruce L.
Fibrogen Inc.
Henry Ford Health System
Mbm Intellectual Property Law Llp
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