Methods for detecting regulatory effect on synoviolin activity

C - Chemistry – Metallurgy – 12 – N

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C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 29/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/26 (2006.01) C12Q 1/48 (2006.01) C40B 30/06 (2006.01)

Patent

CA 2536071

It is intended to provide a method for evaluating an effect of controlling the activity of proline 4-hydroxyolase; a screening method with the use of the above evaluation method; and a method of screening a compound which is useful in treating or preventing fibrosis or rheumatoid arthritis. A method for detecting an effect of controlling the ubiquitination activity of proline 4-hydroxyolase .alpha. subunit (P4HA1) by synoviolin; and a method of screening a substance having an effect of controlling the ubiquitination activity of P4HA1 of synoviolin based on the above method. A compound found out by this screening is useful in treating or preventing diseases caused by disorders in the activity of proline 4-hydroxylase such as fibrosis and rheumatoid arthritis.

L'invention vise à l'obtention d'un procédé d'évacuation d'un effet de régulation de l'activité de proline 4-hydroxyolase; un procédé de criblage à l'aide du procédé d'évaluation précité; et un procédé de criblage d'un composé utile pour traiter ou pour prévenir la fibrose ou la polyarthrite rhumatoïde. L'invention concerne également un procédé de détection d'un effet de régulation de l'activité d'ubiquitination de la sous-unité .alpha. de proline 4-hydroxyolase (P4HA1) par synoviolin; et un procédé de criblage d'une substance ayant un effet de régulation de l'activité d'ubiquitination de P4HA1 de synoviolin sur la base du procédé précité. Un composé découvert par ce criblage est utile pour traiter ou pour prévenir des maladies provoquées par des troubles dans l'activité de proline 4-hydroxylase telle que la fibrose et la polyarthrite rhumatoïde.

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