Methods for detecting substances which bind to the amyloid...

Details Methods for detecting substances which bind to the amyloid... Methods for detecting substances which bind to the amyloid...

C - Chemistry, Metallurgy

07

D

C07D 307/79 (2006.01) A61K 31/343 (2006.01) A61K 31/41 (2006.01) A61P 25/28 (2006.01) C07D 405/12 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2561532

Disclosed are methods for identifying and evaluating the binding properties of substances to the amyoid precursor protein (APP) or to &bgr;-amyloid (A&bgr;) fragments of APP. Also disclosed is a class of benzofuran derivatives of formula (I), which interact specifically with APP or A&bgr;, and block interaction of APP or A&bgr; with secreatase or APP or A&bgr; binding antibodies.

L'invention concerne des méthodes d'identification et d'évaluation des propriétés de fixation de substances à la protéine précurseur amyloïde (APP) ou à des fragments .beta.-amyloïdes (A?) de PPA. L'invention concerne également une classe de dérivés benzofurane de la formule (I), lesquels interagissent spécifiquement avec PPA ou A.beta., et bloquent l'interaction de PPA ou A.beta. avec des anticorps fixant la secrétase ou PPA ou A.beta..

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