C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12N 15/55 (2006.01) C12Q 1/04 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) C12N 9/16 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2604143
Antibodies to a LAR phosphatase subunit, particularly antibodies having specificity to an intracellular domain of a phosphatase subunit, methods for generation thereof and cells producing these antibodies, and determination and examination methods of LAR/LAR derived molecules using these antibodies, as well as uses of these antibodies in diagnosis and therapy of thyroid cancer are disclosed. Also disclosed are methods for detecting thyroid carcinoma from thyroid cells in a clinical specimen.
Le brevet porte sur la divulgation d'anticorps dirigés contre la sous-unité de la phosphatase LAR, en particulier d'anticorps présentant une spécificité envers un domaine intracellulaire de la sous- unité de la phosphatase, de méthodes permettant de les produire, de cellules produisant ces anticorps et de méthodes permettant de mesurer et d'étudier LAR ou des molécules dérivées de LAR à l'aide de ces anticorps, de même que l'utilisation de ces anticorps dans le diagnostic et le traitement du cancer de la thyroïde. Aussi, l'invention porte sur des méthodes permettant de déceler un carcinome de la thyroïde à partir de cellules de la thyroïde d'un échantillon clinique.
Konishi Noboru
Tsujikawa Kazutake
Uchino Yukiko
Yamamoto Hiroshi
Fuso Pharmaceutical Industries Ltd.
Kirby Eades Gale Baker
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