C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/09 (2010.01) C12N 5/071 (2010.01) C12Q 1/68 (2006.01) C40B 30/00 (2006.01) C40B 40/06 (2006.01) G01N 33/48 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2677000
[00153] Described herein are methods and compositions for determining whether a particular cancer is resistant to or susceptible to a histone deacetylase inhibitor or to histone deacetylase inhibitors. The methods include analysis of the expression levels of at least four biomarker genes associated with response to a histone deacetylase inhibitor. Also described herein are methods and compositions for increasing the likelihood of a therapeutically effective treatment in a patient, comprising an analysis of the expression levels of at least four biomarker genes associated with response to a histone deacetylase inhibitor. Also described herein are isolated populations of nucleic acids derived from a cancer sensitive to or resistant to a histone deacetylase inhibitor. Further described are kits and indications that are used in conjunction with the aforementioned methods and compositions.
[00153] La présente invention concerne des procédés et des compositions permettant de déterminer si un cancer particulier résiste ou est sensible à l'inhibiteur de l'histone déacétylase ou des inhibiteurs de l'histone déacétylase. Les procédés comprennent l'analyse des niveaux d'expression d'au moins quatre gènes de biomarqueurs associés à la réponse à un inhibiteur de l'histone déacétylase. L'invention porte aussi sur des procédés et des compositions permettant d'augmenter la possibilité d'un traitement efficace d'un point de vue thérapeutique pour le patient, qui comprennent une analyse des niveaux d'expression d'au moins quatre gènes de biomarqueurs associés à la réponse à un inhibiteur de l'histone déacétylase. L'invention se rapporte en outre à des populations isolées d'acides nucléiques dérivés d'un cancer sensible ou résistant à l'inhibiteur de l'histone déacétylase. De plus, l'invention a trait à des kits et des indications utilisés avec les procédés et les compositions susmentionnés.
Balasubramanian Sriram
Buggy Joseph J.
Pharmacyclics Inc.
Smart & Biggar
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