Methods for determining genotoxic states from nuclear dna...

Details Methods for determining genotoxic states from nuclear dna... Methods for determining genotoxic states from nuclear dna...

G - Physics

01

N

G01N 21/35 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2186704

The invention relates to diagnostic methods for determining the genotoxic state or phenotype of a specimen by analyzing its nuclear DNA through spectral analysis. In combination with the discovery that there is a non-random progression of structural alterations of nuclear DNA from a healthy or non-genotoxic state to a carcinomicstate and further to a metastatic state (both genotoxic states), a comparison between a specimens' nuclear DNA obtained by spectral analysis to a reference spectra will yield a state genotoxic state determination based upon a specimen's nuclear DNA phenotype, irrespective of histological evidence of neoplasia or other aberrant cellular reproduction such as cancer or metastasis.

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