A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7088 (2006.01) A61P 35/00 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) C12N 15/113 (2010.01)
Patent
CA 2690144
The invention provides a method of determining an HCC subtype in a subject comprising a) obtaining a sample from the subject, b) assaying the sample to detect the expression of 1 or more biomarkers, and c) correlating the expression of the biomarkers with an HCC subtype in a subject. The invention further provides methods of detecting HCC stem cells in a sample. Additionally, the invention provides methods and compositions for treating subjects with HCC that take advantage of the biomarkers associated with HCC stem cells.
L'invention propose un procédé de détermination d'un sous-type de HCC chez un sujet comportant a) l'obtention d'un échantillon provenant du sujet, b) l'analyse de l'échantillon afin de détecter l'expression d'un ou de plusieurs biomarqueurs, et c) la corrélation de l'expression des biomarqueurs avec un sous-type de HCC chez un sujet. L'invention propose en outre des procédés de détection de cellules souches de HCC dans un échantillon. De plus, l'invention propose des procédés et des compositions pour traiter des sujets avec HCC qui tirent profit des biomarqueurs associés avec des cellules souches de HCC.
Croce Carlo M.
Ji Junfang
Wang Xin Wei
Yamashita Taro
Ridout & Maybee Llp
The Government Of The United States Of America As Represented By
The Ohio State University Research Foundation
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