Methods for determining platelet function

Details Methods for determining platelet function Methods for determining platelet function

C - Chemistry, Metallurgy

12

Q

C12Q 1/56 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2160982

The invention provides a memos for determining platelet activation in a mammal in response to von Willebrand factor (vWf) comprising providing platelets from the mammal, contacting the platelets in suspension with immobilised vWf or an effective fragment or analog thereof while applying to the platelets an effective mechanical stimulus for an effective period of time and determining the platelet activation produced. The invention also provides a method for detecting a bleeding disorder in a human. Further, the invention provides a method for monitoring the efficacy of pharmacological agents affecting platelet function in vivo.

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