Methods for diagnosing aml and mds differential gene expression

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2524173

Methods, systems and equipment for diagnosing or monitoring the progression or treatment of AML or MDS. This invention identifies a plurality of AML or MDS disease genes which are differentially expressed in bone marrow cells of AML or MDS patients as compared to disease-free humans. These AML or MDS disease genes can be used as molecular markers for detecting the presence or absence of AML or MDS. These genes can also be used for the early identification of MDS patients who eventually progress to AML.

La présente invention concerne des techniques, des systèmes et un matériel permettant de diagnostiquer ou de surveiller la progression ou le traitement d'une leucémie LAM ou d'un syndrome myélodisplasique (MDS). Cette invention identifie une pluralités de gènes de maladie LAM ou MDS qui sont exprimés différemment dans des cellules de moelle osseuse de patient atteint de LAM ou de MDS comparée à celles de personnes non malades. Ces gènes de maladie LAM ou MDS peuvent être utilisés comme marqueurs moléculaires destinés à détecter la présence ou l'absence de LAM ou de MDS. On peut aussi utiliser ces gènes pour identifier précocement des patients atteints de MDS qui ultérieurement évolue en LAM..

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