Methods for diagnosing and evaluating cancer

Details Methods for diagnosing and evaluating cancer Methods for diagnosing and evaluating cancer

G - Physics

01

N

G01N 33/574 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2328112

Methods for diagnosing cancer, such as prostate, ovarian or breast cancer, as well as leukemia, are provided. Such methods may employ binding agents, such as antibodies or CAR sequences of OB-cadherin or N-cadherin, that specifically bind to OB-cadherin or N-cadherin, or polynucleotides that hybridize to a polynucleotide encoding OB-cadherin or N-cadherin. Also provided are methods for monitoring the progression of a cancer and to evaluate the metastatic potential of a cancer.

Procédés servant à diagnostiquer le cancer, tel que le cancer de la prostate, des ovaires ou du sein, ainsi que la leucémie. Ces procédés peuvent mettre en application des agents de liaison, tels que des anticorps ou des séquences de CAR de OB-cadhérine ou N-cadhérine se fixant spécifiquement à OB-cadhérine ou N-cadhérine, ou des polynucléotides s'hybridant à un polynucléotide codant OB-cadhérine ou N-cadhérine. Procédés servant à contrôler la progression d'un cancer et à évaluer le potentiel métastatique d'un cancer.

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