Methods for diagnosing and treating autoimmune disease

Details Methods for diagnosing and treating autoimmune disease Methods for diagnosing and treating autoimmune disease

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 38/53 (2006.01) A61K 45/00 (2006.01) C12N 9/12 (2006.01) C12Q 1/02 (2006.01) C12Q 1/37 (2006.01) C12Q 1/48 (2006.01) G01N 33/564 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2321959

The invention provides a method of detecting autoimmune disease in a mammal, comprising providing a biological sample from a mammal and detecting proteasome activity, wherein a reduction in proteasome activity from a basal state is indicative of autoimmune disease. In addition, the invention encompasses a method of treating an autoimmune disease in a mammal, comprising administering to a mammal suspected of suffering from an autoimmune disease an agent which restores NFB activity in an amount and for a time sufficient to result in normal NFB activity in the mammal.

L'invention concerne une méthode de détection d'une maladie auto-immune chez un mammifère, qui consiste à obtenir un échantillon biologique d'un mammifère et à détecter une activité protéasomique. Une réduction de ladite activité protéasomique à partir d'un état de base indique que le mammifère souffre d'une maladie auto-immune. En outre, l'invention décrit une méthode de traitement d'une maladie auto-immune chez un mammifère, qui consiste à administrer à un mammifère atteint d'une maladie auto-immune un agent qui rétablit l'activité NF?B en quantité et pendant une période suffisantes pour rétablir une activité NF?B normale chez le mammifère.

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