Methods for diagnosing and treating body weight related...

A - Human Necessities – 61 – K

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A61K 39/00 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2276691

A method for determining if an animal is at risk for a body weight related disorder is described. An animal is provided and an aspect of ICAM receptor or .beta.2 integrin metabolism or structure is evaluated in the animal. An abnormality in the aspect of ICAM receptor or .beta.2 integrin metabolism or structure is diagnosed of being at risk for a body weight related disorder. Also described are methods for detecting the presence of a disease affecting body weight, methods for evaluating an agent for use in modulating body weight, methods for treating a body weight related disorder, methods for monitoring a therapeutic treatment of a disease affecting body weight, and methods for increasing the fat content in the liver or milk of an animal. Pharmaceutical compositions are also provided.

On décrit un procédé permettant de déterminer si un animal présente un risque de développer un trouble lié au poids corporel. On choisit un animal et on évalue chez cet animal un aspect du récepteur ICAM ou du métabolisme ou de la structure de l'intégrine .beta.¿2?. Un aspect anormal du récepteur ICAM ou bien du métabolisme ou de la structure de l'intégrine .beta.¿2? déclenche un diagnostic de risque de développer un trouble lié au poids corporel. On décrit également des procédés de détection de la présence d'une maladie affectant le poids corporel, des procédés d'évaluation d'un agent destiné à être utilisé pour moduler le poids corporel, des procédés de traitement d'un trouble lié au poids corporel, des procédés de surveillance d'un traitement thérapeutique d'une maladie affectant le poids corporel et des procédés permettant d'augmenter la teneur en graisse du foie ou du lait d'un animal. Des compositions pharmaceutiques sont également décrites.

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