Methods for diagnosing and treating hemostatic disorders by...

Details Methods for diagnosing and treating hemostatic disorders by... Methods for diagnosing and treating hemostatic disorders by...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 35/14 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2408883

The present invention identifies P-selectin as a modulator of hemostasis. Accordingly, the present invention relates to methods for the identification and use of modulators of P-selectin activity as modulators of hemostasis. The invention also relates to methods and compositions for the diagnosis and treatment of hemostatic disorders, including, but not limited to, hemorrhagic disorders and thrombotic disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hemostatic conditions, and for the identification of subjects exhibiting a predisposition to such conditions. In addition, the present invention provides methods for the diagnostic monitoring of patients undergoing clinical evaluation for the treatment of hemostatic or vascular disorders, and for monitoring the efficacy of compounds in clinical trials.

Cette invention a permis d'identifier la P-sélectine comme modulateur de l'hémostase. Cette invention propose ainsi des procédés pour identifier et utiliser des modulateurs d'activité de la P-sélectine comme modulateurs de l'hémostase. Cette invention concerne également des procédés et des compositions pour diagnostiquer et traiter des troubles hémostatiques, tels que notamment les affections hémorragiques et les affections thrombotiques. Cette invention décrit des procédés pour l'évaluation diagnostique et le pronostic de divers états hémostatiques et pour l'identification de sujets ayant une prédisposition à de tels états. Cette invention concerne en outre des procédés pour le suivi diagnostic de patients sous évaluation clinique pour le traitement de troubles hémostatiques ou vasculaires, et pour le suivi de l'efficacité de composés dans des essais cliniques.

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