C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) G01N 33/48 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2457823
Described is a method for diagnosing a neoplasia by determining whether the level of one or more NF-AT transcription factor(s) is reduced. Moreover, methods for screening compounds which activate an NF-AT or which mimic the function of NF-AT are disclosed. Also disclosed are methods for the prevention or treatment of neoplasias by increasing the activity of an NF-AT.
La présente invention se rapporte à un procédé permettant de diagnostiquer une néoplasie et consistant à déterminer une réduction éventuelle du taux d'un ou de plusieurs facteurs de transcription NF-AT. L'invention se rapporte en outre à des procédés de sélection de composés qui activent un facteur NF-AT ou qui imitent la fonction d'un facteur NF-AT. L'invention se rapporte également à des procédés de prévention ou de traitement des néoplasies par accroissement de l'activité d'un facteur NF-AT.
Avots Andris
Chuvpilo Sergey
Serfling Edgar
Avots Andris
Chuvpilo Sergey
Ridout & Maybee Llp
Serfling Edgar
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