Methods for diagnosing epigenetic, transgenerational effects...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/01 (2006.01) A61K 31/70 (2006.01) A61K 38/00 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2608850

The present invention provides methods for detecting epigenetic, multigenerational DNA alterations caused by toxicants such as endocrine disruptor agents in a subject. The practice of the present invention can be used to diagnose and/or treat a subject having the identified DNA alterations by developing therapeutics, to prevent or delay the onset of associated diseases and/or dysfunctions.

La présente invention concerne des méthodes permettant de détecter des altérations épigénétiques multigénérationnelles de l'ADN causées par des substances toxiques telles que des agents dérégulateurs endocriniens chez un sujet. La présente invention peut servir à diagnostiquer et/ou traiter un sujet présentant les altérations de l'ADN identifiées en développant des thérapies, ainsi qu'à prévenir ou à repousser l'apparition de maladies et/ou de dysfonctionnements associés.

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