Methods for diagnosing human influenza and 4-position...

Details Methods for diagnosing human influenza and 4-position... Methods for diagnosing human influenza and 4-position...

C - Chemistry, Metallurgy

07

H

C07H 15/203 (2006.01) C07H 13/04 (2006.01) C07H 15/04 (2006.01) C07H 17/02 (2006.01) C07H 17/075 (2006.01) C12Q 1/34 (2006.01) G01N 33/52 (2006.01)

Patent

CA 2072368

Chromogenic derivatives of N-acetylneuraminic acid modified in the 4-position by eliminating the hydroxyl group, by replacing the hydroxyl group with fluorine, or by replacing the hydrogen of the hydroxyl group with methyl are used as substrates in colorimetric assays for human influenza neuraminidase activity in clinical specimens for the purpose of selectively diagnosing influenza infection. The substrates may exhibit different reactivity with the different types of influenza neuraminidases, thus enabling one to discern the specific type of influenza infection and prescribe appropriate treatment and/or supportive therapy therefor.

Dérivés chromogènes de l'acide N-acétylneuraminique, modifiés en position 4 par élimination du groupe hydroxyle, par remplacement du groupe hydroxyle par du fluor, ou par remplacement de l'hydrogène du groupe hydroxyle par un méthyle; ils sont employés comme substrats pour des analyses colorimétriques de l'activité de la neuraminidase de la grippe chez l'homme, dans des échantillons cliniques aux fins de diagnostic sélectif de l'infection grippale. Les substrats peuvent présenter différentes réactivités selon le type de neuraminidase de la grippe, permettant ainsi de déceler le type spécifique d'infection grippale et de prescrire le traitement et (ou) la thérapie de soutien appropriés.

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