Methods for diagnosis and therapy of autoimmune disease,...

Details Methods for diagnosis and therapy of autoimmune disease,... Methods for diagnosis and therapy of autoimmune disease,...

C - Chemistry, Metallurgy

12

N

C12N 15/48 (2006.01) A01K 67/027 (2006.01) A61K 38/08 (2006.01) A61K 39/21 (2006.01) C07H 19/06 (2006.01) C07K 7/06 (2006.01) C07K 14/15 (2006.01) C07K 16/10 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/55 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/50 (2006.01) G01N 33/543 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2297491

The invention relates to a process for the diagnosis of a human autoimmune disease, including presymptomatic diagnosis, said human autoimmune disease being associated with human endogenous retrovirus (HERV) having Superantigen (SAg) activity, comprising specifically detecting in a biological sample of human origin at least one of the following: (I) the mRNA of an expressed human endogenous retrovirus having Superantigen (SAg) activity, or fragments of such expressed retroviral mRNA, said retrovirus being associated with a given autoimmune disease, or (II) protein or peptide expressed by said retrovirus, or (III) antibodies specific to the protein expressed by said endogenous retrovirus, or (IV) SAg activity specifically associated with said endogenous retrovirus, detection of any of the species (I) to (IV) indicating presence of autoimmune disease or imminent onset of autoimmune disease.

L'invention porte sur une méthode diagnostique d'une maladie auto-immune humaine, telle que le diagnostic symptomatique, cette maladie auto-immune étant associée au rétrovirus endogène humain (HERV) ayant une activité de superantigène (SAg). Cette méthode consiste à détecter dans un échantillon biologique d'origine humaine au moins un des éléments suivants: I- l'ARNm d'un rétrovirus endogène humain exprimé ayant une activité de superantigène (SAg), ou des fragments de cet ARNm rétroviral exprimé, le rétrovirus étant associé à une maladie auto-immune donnée, ou II- une protéine ou un peptide exprimé par le rétrovirus, ou III- des anticorps spécifiques aux protéines exprimées par le rétrovirus endogène, ou IV- l'activité SAg spécifiquement associée au rétrovirus endogène. L'invention porte également sur la détection d'une quelconque de ces espèces I à IV indiquant la présence d'une maladie auto-immune ou de son apparition imminente.

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