Methods for diagnosis anf monitoring of neurological disease...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/02 (2006.01) G01N 21/31 (2006.01) G01N 33/483 (2006.01)

Patent

CA 2514327

Encephalotoxin produced by activated mononuclear phagocytes is present in individuals having neurological disease including neurodegenerative and neuro- inflammatory diseases, such as Alzheimer's disease (AD), HIV-1-associated dementia (HAD), Creutzfeld-Jakob disease, Mild Cognitive Impairment, prion disease, mild cognitive/ motor dysfunction, acute stroke, acute trauma, or neuro-AIDS. Biochemical detection of encephalotoxin according to the methods of the invention will allow diagnosis of neurological disease in early, presymptomatic stages, thereby allowing early intervention in disease progression as well as identification of subjects or populations at risk for developing neurodegenerative disease. The methods of the invention also provide a mechanism for monitoring progression and treatment of neurological disease.

Selon cette invention, une encéphalotoxine produite par des phagocytes mononucléaires activés est présente chez des individus présentant une maladie neurologique, notamment des maladies neurodégénératives et neuro-inflammatoires telles que la maladie d'Alzheimer (AD), une démence associée au HIV-1 (HAD), la maladie de Creutzfeld-Jakob, une déficience cognitive légère, une maladie à prions, un dysfonctionnement cognitif/moteur léger, un accident cérébral vasculaire aigu, un traumatisme aigu ou un neuro-SIDA. La détection biochimique de l'encéphalotoxine selon les procédés de cette invention permettra le diagnostic de la maladie neurologique à des stades précoces, présymptomatiques, ce qui permettra une intervention précoce dans la progression de la maladie ainsi que dans l'identification de sujets ou de populations à risque pour le développement d'une maladie neurodégénérative. Les procédés de cette invention concernent également un mécanisme de surveillance de la progression et du traitement d'une maladie neurologique.

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