Methods for distinguishing isomers using mass spectrometry

Details Methods for distinguishing isomers using mass spectrometry Methods for distinguishing isomers using mass spectrometry

G - Physics

01

N

G01N 24/00 (2006.01)

Patent

CA 2644499

A method of distinguishing dimethylarginine isomers using tandem mass spectrometry is disclosed. The method includes the steps of ionizing a sample to generate ions; selecting ions having a mass-to-charge ratio (m/z) in an m/z range; fragmenting the selected ions t produce daughter ions; and detecting one or both of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in the sample by detecting one or both of a daughter ion m/z signal at a m/z unique to ADMA and a daughter ion m/z signal at a m/z unique to SDMA.

L'invention concerne des procédés permettant de distinguer des isomères de diméthylarginine. L'invention concerne également des procédés et des compositions permettant de diagnostiquer des troubles cardiovasculaires.

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