C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C07K 14/37 (2006.01) C07K 14/39 (2006.01) C07K 14/435 (2006.01) C12N 1/14 (2006.01) C12N 1/15 (2006.01) C12N 1/16 (2006.01) C12N 1/19 (2006.01) C12N 9/10 (2006.01) C12N 15/31 (2006.01) C12P 21/00 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2551484
The present invention relates to the elimination of mannosylphosphorylation on the glycans of glycoproteins in the yeast genus Pichia. The elimination of mannosylphosphorylated glycoproteins results from the disruption of the PNO1 gene and the newly isolated P. pastoris MNN4B gene. The present invention further relates to methods for producing modified glycan structures in host cells that are free of glycan mannosylphosphorylation.
L'invention concerne l'élimination de la mannosylphosphorylation sur les glycanes des glycoprotéines dans la levure du genre Pichia. L'élimination des glycoprotéines mannosylphosphorylées découle de la dislocation du gène <I>PNO1</I> et du gène P. pastoris MNN4B nouvellement isolé. L'invention concerne en outre des procédés de production de structures de glycane modifiées dans des cellules hôtes qui sont exemptes de mannosylphosphorylation de glycane.
Bobrowicz Piotr
Stadheim Terrance
Wildt Stefan
Glycofi Inc.
Smart & Biggar
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