C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) C07K 16/46 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2548950
Antihuman Mpl antibody is obtained and purified. By using a genetic engineering technique, a single chain antibody of the antihuman Mpl antibody is further constructed. This antibody shows a high agonistic activity. This fact indicates that the activity of an antibody can be reinforced by binding two or more heavy chain variable domains to two or more light chain variable domains with the use of a linker to give a single chain polypeptide.
L'invention concerne l'obtention et la purification d'un anticorps Mpl anti-humain. La mise en oeuvre d'une technique d'ingénierie génétique permet de construire un anticorps à chaîne unique de l'anticorps Mpl anti-humain. Cet anticorps possède une activité agoniste élevée, indiquant que l'activité d'un anticorps peut être renforcée par liaison d'au moins deux domaines variables des chaînes lourdes à au moins deux domaines variables des chaînes légères, au moyen d'un liant, de manière à obtenir un polypeptide à chaîne unique.
Ohtomo Toshihiko
Tsuchiya Masayuki
Tsunoda Hiroyuki
Yabuta Naohiro
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Chugai Seiyaku Kabushiki Kaisha
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