Methods for enhancing exercise performance

Details Methods for enhancing exercise performance Methods for enhancing exercise performance

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/33 (2006.01) A61K 31/426 (2006.01) C40B 30/04 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2672420

Disclosed herein are methods for enhancing one or more effects of exercise in a subject by administering a PPAR.delta. agonist {e.g., GW1516) to the subject in combination with an exercise program. Also disclosed are gene expression profiles unique to the combination of agonist-induced PPAR.delta. activation and exercise. Such profiles are useful, at least, in methods for identifying the use of performance-enhancing drugs in exercised subjects (such as, professional or athletes). Direct interactions between PPAR.delta. and exercised-induced kinases {e.g., AMPK or its subunits, AMPK .alpha.l and/or AMPK .alpha.2) also are disclosed. Such protein-protein interactions provide new targets for identification of useful compounds.

L'invention concerne des procédés permettant une amélioration d'un ou plusieurs effets d'un exercice chez un sujet par l'administration d'un agoniste PPARd (par exemple, GW1516) au sujet en combinaison avec un programme d'exercice. L'invention concerne également des profils d'expression des gènes qui sont uniques à la combinaison d'activation PPARd induite par l'agoniste et de l'exercice. De tels profils sont utiles, au moins, dans des procédés permettant d'identifier l'utilisation de médicaments améliorant les performances chez des sujets entraînés (tels que des professionnels ou des athlètes). L'invention concerne également des interactions directes entre le PPARd et des kinases induites par l'exercice (par exemple, AMPK ou ses sous-unités, AMPK a1 et/ou AMPK a2). De telles interactions protéine-protéine offrent de nouvelles cibles pour l'identification de composés utiles.

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