Methods for enhancing muscle performance and tone

Details Methods for enhancing muscle performance and tone Methods for enhancing muscle performance and tone

A - Human Necessities

61

K

A61K 31/7056 (2006.01) A61K 31/426 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2710764

Agonists of AMP-activated protein kinase (AMPK) im-prove exercise and modify energy metabolism in a subject A combination of AMPK and peroxisome proliferator-activated receptor (PPAR) delta ag-onists may also be used to improve exercise performance in a subject Methods for identifying substance-enhanced exercise performance in a subject, and methods for identifying compounds that affect the interaction of PPAR6 with exercise-induced kinases are also disclosed.

L'invention porte sur l'utilisation d'agonistes de l'AMPK (protéine kinase activée par l'AMP) pour améliorer les effets de l'exercice et modifier le métabolisme énergétique chez un sujet. L'invention porte également sur une combinaison d'agonistes de l'AMPK et de PPARd (récepteur activé par les proliférateurs des peroxisomes), permettant d'améliorer les performances lors de l'exercice chez un sujet, sur des méthodes d'identification de performances lors de l'exercice, améliorées au moyen de substances chez un sujet, et sur des méthodes d'identification de composés modifiant l'interaction entre le PPARd et les kinases induites par l'exercice.

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