C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) C12N 15/10 (2006.01)
Patent
CA 2417344
Methods are presented for enhancing the efficiency of oligonucleotide-mediated repair or alteration of genetic information. The methods comprise using cells or cell-free extracts having altered levels or activity of at least one protein from the RAD52 epistasis group, the mismatch repair group or the nucleotide excision repair group. Kits and compositions are also presented.
La présente invention concerne des méthodes d'augmentation de l'efficacité de la réparation ou de l'altération d'informations génétiques dirigée à l'aide d'oligonucléotides. Ces méthodes consistent à utiliser des extraits cellulaires ou acellulaires présentant une activité ou des niveaux modifiés d'au moins une protéine du groupe d'épistasie RAD52, du groupe de réparation des mésappariements ou du groupe de réparation de l'excision nucléotidique. De plus, l'invention concerne des kits et des compositions associés.
Gamper Howard B.
Kmiec Eric B.
Liu Li
Rice Michael C.
Smart & Biggar
University Of Delaware
LandOfFree
Methods for enhancing targeted gene alteration using... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods for enhancing targeted gene alteration using..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods for enhancing targeted gene alteration using... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1555934