Methods for enhancing the production of cytokines in cell...

Details Methods for enhancing the production of cytokines in cell... Methods for enhancing the production of cytokines in cell...

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01) C12N 15/67 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2376487

The present invention is directed to methods for enhancing the production of cytokines in mammalian cell culture by modifying the level of a cytokine regulatory factor in the cells, resulting in enhanced levels of cytokine production. The invention is further directed to cell lines which exhibit enhanced cytokine regulatory factor expression and enhanced cytokine expression.

Cette invention a trait à des procédés visant à augmenter la production de cytokines dans une culture de cellules de mammifère et ce, par le biais d'une modification du taux d'un facteur de régulation de la cytokine dans les cellules, ce qui se traduit par des niveaux accrus de production de cytokine. L'invention concerne également des lignées cellulaires présentant une expression accrue de facteur de régulation de la cytokine ainsi qu'une augmentation de l'expression de la cytokine.

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