Methods for enhancing the therapeutic efficacy of...

Details Methods for enhancing the therapeutic efficacy of... Methods for enhancing the therapeutic efficacy of...

A - Human Necessities

61

K

A61K 31/4406 (2006.01) A61K 31/4745 (2006.01) A61K 31/7048 (2006.01) A61P 35/00 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2675834

Disclosed are methods and compositions useful in identifying an E3 ubiquitin ligase inhibitor and modulating cell growth, comprising contacting a cell with an effective amount of an inhibitor of an E3 ubiquitin ligase, and contacting the cell with an effective amount of a topoisomerase inhibitor, wherein the treatment with the E3 ubiquitin ligase inhibitor and topoisomerase inhibitor modulates cell growth in comparison to a cell treated with the topoisomerase inhibitor alone. The present invention further provides methods for identifying and making an E3 ubiquitin ligase inhibitor.

L'invention concerne des procédés et des compositions qui permettent d'identifier un inhibiteur de l'ubiquitine E3 ligase et de moduler la croissance cellulaire. Les procédés de l'invention consistent à mettre une cellule en contact avec une quantité efficace d'un inhibiteur de l'ubiquitine E3 ligase, et à mettre la cellule en contact avec une quantité efficace d'un inhibiteur de la topoisomérase, le traitement par l'inhibiteur de l'ubiquitine E3 ligase et l'inhibiteur de la topoisomérase modulant la croissance cellulaire par comparaison avec une cellule traitée par l'inhibiteur de la topoisomérase seul. L'invention se rapporte en outre à des procédés d'identification et de fabrication d'un inhibiteur de l'ubiquitine E3 ligase.

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