Methods for enhancing vascularization of implant devices

A - Human Necessities – 61 – L

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A61L 27/00 (2006.01) A61K 38/13 (2006.01) A61L 27/38 (2006.01) A61M 37/00 (2006.01) B65D 5/42 (2006.01)

Patent

CA 2148354

2148354 9508355 PCTABS00036 Methods for enhancing vascular support of cells housed within an implanted apparatus are disclosed. The methods comprise placing a population of therapeutic substance-producing cells into the cell receiving chamber of an immunoisolation apparatus, implanting the apparatus into a patient, and administering an immunomodulatory agent to the patient. The immunomodulatory agent increases the number of close vascular structures in the vicinity of the implanted device, which increases the long term survival of the cell population housed therein.

Cette invention concerne des procédés permettant d'augmenter le support vasculaire de cellules logées dans un appareil implanté. Ces procédés consistent à placer une population de cellules produisant une substance thérapeutique dans la chambre de réception cellulaire d'un appareil d'immuno-isolement; à implanter l'appareil chez un patient; puis à administrer un agent immunomodulateur à ce dernier. Cet agent immunomodulateur accroît le nombre de structures vasculaires proches situées au voisinage du dispositif implanté, ce qui augmente la survie à long terme de la population de cellules qui s'y trouve.

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