Methods for eosinophil depletion and compositions therefor

Details Methods for eosinophil depletion and compositions therefor Methods for eosinophil depletion and compositions therefor

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2288017

Binding compositions and various methods of use of the binding compositions are provided. In particular, a method is provided which comprises administering an effective amount of the binding composition, alone or in combination with other compounds, to eosinophils, thereby reducing the level of eosinophils in an individual. Preferably, the binding composition is a monoclonal antibody specific for CCR3.

L'invention a trait à des compositions de fixation ainsi qu'à diverses méthodes d'utilisation de celles-ci. Elle porte, notamment, sur une méthode consistant à apporter une quantité efficace de la composition de fixation, seule ou associée à d'autres composés, à des éosinophiles, ce qui pour effet d'en réduire la concentration chez un sujet. La composition de fixation est, de préférence, un anticorps monoclonal spécifique de CCR3.

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