A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61B 1/00 (2006.01) A61K 31/7088 (2006.01) A61P 29/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2510362
The invention discloses a knockout mouse that is homozygous for a RUNX3 null allele, as a novel model for chronic inflammatory disease. The present invention provides methods for treating T cell-related inflammatory conditions by cell therapy, gene therapy or antisense for up regulating or down regulating RUNX3. The invention further relates to methods of diagnosing and assessing predisposition to chronic inflammatory diseases. The present invention further provides methods for testing agents for effectiveness in treating and/or preventing diseases associated with chronic inflammatory or autoimmune conditions.
L'invention concerne une souris knockout homozygote pour un allèle nul RUNX3, en tant que nouveau modèle de maladie inflammatoire chronique. Cette invention présente des procédés de traitement de troubles inflammatoires liés aux lymphocytes T par thérapie cellulaire, thérapie génique ou antisens en vue de réguler le RUNX3 de manière positive ou négative. En outre, cette invention concerne des procédés de diagnostic et de vérification des prédispositions à ces maladies inflammatoires chroniques, ainsi que des procédés de test d'agents quant à leur efficacité dans le traitement et/ou la prévention de maladies associées à des troubles auto-immuns ou inflammatoires chroniques.
Bettoun David
Groner Yoram
Ltd. Yeda Research And Development Co.
Ridout & Maybee Llp
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